Connective tissue activation. XXIII. Increased plasma levels of a platelet growth factor (CTAP-III) in patients with rheumatic diseases.
نویسندگان
چکیده
Plasma levels of the CTAP-III antigen were measured by radioimmunoassay in 80 patients with rheumatic diseases. Patients with clear evidence of vasculitis usually exhibited increased plasma CTAP-III antigen. In both systemic lupus erythematosus and rheumatoid arthritis, there appeared to be a correlation between pCTAP-III values and other laboratory and clinical parameters of disease activity.
منابع مشابه
XXXVI. The Origin, Variety, Distribution, and Biologic Fate of Connective Tissue Activating Peptide-I11 Isoforms: Characteristics in Patients with Rheumatic, Renal, and Arterial Disease
Objective. To determine the origin, distribution, and biologic fate of platelet-derived connective tissue activating peptid+III (CTAP-111), to define the relative amounts of the antigen forms (CTAP-111, betathromboglobulin [@-TG], neutrophil activating peptide-2 [NAP-21) in plasma of normal persons and those with rheumatic or end-stage renal disease, and to define the isoforms of CTAP-I11 in pl...
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The platelet-derived connective tissue activating peptide (CTAP-III) has been shown to be an important factor stimulating the metabolism and proliferation of human connective tissue cell strains, including synovial tissue cells. The quantities of CTAP-III affecting the cellular changes and the amounts of various biologic fluids and tissues are small. The objectives of this study were to develop...
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متن کاملStructural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.
Connective tissue activating peptides (CTAPs) extracted from leukocytes and platelets stimulate glycolysis and synthesis of glycosaminoglycan and DNA in cultured human connective tissue cells. CTAP-III, isolated from fresh or outdated human platelets, is a low molecular weight single-chain protein with an isoelectric point of 8.5 that markedly stimulates DNA synthesis and multiple aspects of gl...
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ورودعنوان ژورنال:
- Clinica chimica acta; international journal of clinical chemistry
دوره 115 2 شماره
صفحات -
تاریخ انتشار 1981